Action-effect binding is decreased in motor conversion disorder: implications for sense of agency
Identifieur interne : 000B18 ( Main/Exploration ); précédent : 000B17; suivant : 000B19Action-effect binding is decreased in motor conversion disorder: implications for sense of agency
Auteurs : Sarah M. Kranick [États-Unis] ; James W. Moore [Royaume-Uni] ; Nadia Yusuf [États-Unis] ; Valeria T. Martinez [États-Unis] ; Kathrin Lafaver [États-Unis] ; Mark J. Edwards [Royaume-Uni] ; Arpan R. Mehta [Royaume-Uni] ; Phoebe Collins [Royaume-Uni] ; Neil A. Harrison [Royaume-Uni] ; Patrick Haggard [Royaume-Uni] ; Mark Hallett [États-Unis] ; Valerie Voon [Royaume-Uni]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- complications : Conversion Disorder.
- etiology : Mood Disorders.
- psychology : Conversion Disorder.
- Adult, Aged, Awareness, Case-Control Studies, Cooperative Behavior, Dyskinesias, Female, Humans, Male, Middle Aged, Psychomotor Performance, Regression Analysis, Young Adult.
Abstract
The abnormal movements seen in motor conversion disorder are affected by distraction and entrainment, similar to voluntary movement. Unlike voluntary movement, however, patients lack a sense of control for the abnormal movements, a failure of “self-agency.” The action-effect binding paradigm has been used to quantify the sense of self-agency, because subjective contraction of time between an action and its effect only occurs if the subject feels that they are the agent responsible for the action. We used this paradigm, coupled with emotional stimuli, to investigate the sense of agency with voluntary movements in patients with motor conversion disorder.
Twenty patients with motor conversion disorder and 20 age- and gender-matched healthy volunteers used a rotating clock to judge the time of their own voluntary keypresses (action) and a subsequent auditory tone (effect), after completing conditioning blocks in which high, medium and low tones were coupled to images of happy, fearful and neutral faces.
The results replicate those shown previously: an effect following a voluntary action was reported as occurring earlier, and the preceding action later, compared to trials of only keypresses or tones. Patients had reduced overall binding scores relative to healthy volunteers, suggesting a reduced sense of agency. There was no effect of the emotional stimuli (faces) or other interaction effects. Healthy volunteers with subclinical depressive symptoms had higher overall binding scores.
We show that motor conversion disorder patients have decreased action-effect binding for normal voluntary movements compared to healthy volunteers, consistent with the greater experience of lack of control.
Url:
DOI: 10.1002/mds.25408
PubMed: 23494975
PubMed Central: 3701023
Affiliations:
- Royaume-Uni, États-Unis
- Angleterre, Angleterre de l'Est, Grand Londres, Sussex de l'Est
- Brighton, Cambridge, Falmer, Londres
- Université de Cambridge, Université de Londres, Université du Sussex
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Kranick</name><affiliation wicri:level="1"><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD</wicri:regionArea><wicri:noRegion>Bethesda MD</wicri:noRegion></affiliation></author><author><name sortKey="Moore, James W" sort="Moore, James W" uniqKey="Moore J" first="James W." last="Moore">James W. Moore</name><affiliation wicri:level="3"><nlm:aff id="A2">Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Department of Psychology Goldsmiths, University of London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychology Goldsmiths, University of London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Yusuf, Nadia" sort="Yusuf, Nadia" uniqKey="Yusuf N" first="Nadia" last="Yusuf">Nadia Yusuf</name><affiliation wicri:level="1"><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD</wicri:regionArea><wicri:noRegion>Bethesda MD</wicri:noRegion></affiliation></author><author><name sortKey="Martinez, Valeria T" sort="Martinez, Valeria T" uniqKey="Martinez V" first="Valeria T." last="Martinez">Valeria T. Martinez</name><affiliation wicri:level="1"><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD</wicri:regionArea><wicri:noRegion>Bethesda MD</wicri:noRegion></affiliation></author><author><name sortKey="Lafaver, Kathrin" sort="Lafaver, Kathrin" uniqKey="Lafaver K" first="Kathrin" last="Lafaver">Kathrin Lafaver</name><affiliation wicri:level="1"><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD</wicri:regionArea><wicri:noRegion>Bethesda MD</wicri:noRegion></affiliation></author><author><name sortKey="Edwards, Mark J" sort="Edwards, Mark J" uniqKey="Edwards M" first="Mark J." last="Edwards">Mark J. Edwards</name><affiliation wicri:level="3"><nlm:aff id="A4">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mehta, Arpan R" sort="Mehta, Arpan R" uniqKey="Mehta A" first="Arpan R." last="Mehta">Arpan R. Mehta</name><affiliation wicri:level="4"><nlm:aff id="A5">Department of Clinical Neurosciences, Neurology Unit, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurosciences, Neurology Unit, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Collins, Phoebe" sort="Collins, Phoebe" uniqKey="Collins P" first="Phoebe" last="Collins">Phoebe Collins</name><affiliation wicri:level="4"><nlm:aff id="A7">Department of Psychiatry, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Harrison, Neil A" sort="Harrison, Neil A" uniqKey="Harrison N" first="Neil A." last="Harrison">Neil A. Harrison</name><affiliation wicri:level="4"><nlm:aff id="A6">Center for Imaging Sciences, University of Sussex, Falmer, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Imaging Sciences, University of Sussex, Falmer</wicri:regionArea><orgName type="university">Université du Sussex</orgName><placeName><settlement type="city">Brighton</settlement><settlement type="town">Falmer</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Sussex de l'Est</region></placeName></affiliation></author><author><name sortKey="Haggard, Patrick" sort="Haggard, Patrick" uniqKey="Haggard P" first="Patrick" last="Haggard">Patrick Haggard</name><affiliation wicri:level="3"><nlm:aff id="A2">Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name><affiliation wicri:level="1"><nlm:aff id="A1">Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Motor Control Section, Medical Neurology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda MD</wicri:regionArea><wicri:noRegion>Bethesda MD</wicri:noRegion></affiliation></author><author><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name><affiliation wicri:level="4"><nlm:aff id="A7">Department of Psychiatry, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychiatry, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A8">Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Awareness</term><term>Case-Control Studies</term><term>Conversion Disorder (complications)</term><term>Conversion Disorder (psychology)</term><term>Cooperative Behavior</term><term>Dyskinesias</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mood Disorders (etiology)</term><term>Psychomotor Performance</term><term>Regression Analysis</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Conversion Disorder</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Conversion Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Awareness</term><term>Case-Control Studies</term><term>Cooperative Behavior</term><term>Dyskinesias</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Psychomotor Performance</term><term>Regression Analysis</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>BACKGROUND</title><p id="P1">The abnormal movements seen in motor conversion disorder are affected by distraction and entrainment, similar to voluntary movement. Unlike voluntary movement, however, patients lack a sense of control for the abnormal movements, a failure of “self-agency.” The action-effect binding paradigm has been used to quantify the sense of self-agency, because subjective contraction of time between an action and its effect only occurs if the subject feels that they are the agent responsible for the action. We used this paradigm, coupled with emotional stimuli, to investigate the sense of agency with voluntary movements in patients with motor conversion disorder.</p></sec><sec id="S2"><title>METHODS</title><p id="P2">Twenty patients with motor conversion disorder and 20 age- and gender-matched healthy volunteers used a rotating clock to judge the time of their own voluntary keypresses (action) and a subsequent auditory tone (effect), after completing conditioning blocks in which high, medium and low tones were coupled to images of happy, fearful and neutral faces.</p></sec><sec id="S3"><title>RESULTS</title><p id="P3">The results replicate those shown previously: an effect following a voluntary action was reported as occurring earlier, and the preceding action later, compared to trials of only keypresses or tones. Patients had reduced overall binding scores relative to healthy volunteers, suggesting a reduced sense of agency. There was no effect of the emotional stimuli (faces) or other interaction effects. Healthy volunteers with subclinical depressive symptoms had higher overall binding scores.</p></sec><sec id="S4"><title>CONCLUSIONS</title><p id="P4">We show that motor conversion disorder patients have decreased action-effect binding for normal voluntary movements compared to healthy volunteers, consistent with the greater experience of lack of control.</p></sec></div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Grand Londres</li><li>Sussex de l'Est</li></region><settlement><li>Brighton</li><li>Cambridge</li><li>Falmer</li><li>Londres</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Londres</li><li>Université du Sussex</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Kranick, Sarah M" sort="Kranick, Sarah M" uniqKey="Kranick S" first="Sarah M." last="Kranick">Sarah M. Kranick</name></noRegion><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name><name sortKey="Lafaver, Kathrin" sort="Lafaver, Kathrin" uniqKey="Lafaver K" first="Kathrin" last="Lafaver">Kathrin Lafaver</name><name sortKey="Martinez, Valeria T" sort="Martinez, Valeria T" uniqKey="Martinez V" first="Valeria T." last="Martinez">Valeria T. Martinez</name><name sortKey="Yusuf, Nadia" sort="Yusuf, Nadia" uniqKey="Yusuf N" first="Nadia" last="Yusuf">Nadia Yusuf</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Moore, James W" sort="Moore, James W" uniqKey="Moore J" first="James W." last="Moore">James W. Moore</name></region><name sortKey="Collins, Phoebe" sort="Collins, Phoebe" uniqKey="Collins P" first="Phoebe" last="Collins">Phoebe Collins</name><name sortKey="Edwards, Mark J" sort="Edwards, Mark J" uniqKey="Edwards M" first="Mark J." last="Edwards">Mark J. Edwards</name><name sortKey="Haggard, Patrick" sort="Haggard, Patrick" uniqKey="Haggard P" first="Patrick" last="Haggard">Patrick Haggard</name><name sortKey="Harrison, Neil A" sort="Harrison, Neil A" uniqKey="Harrison N" first="Neil A." last="Harrison">Neil A. Harrison</name><name sortKey="Mehta, Arpan R" sort="Mehta, Arpan R" uniqKey="Mehta A" first="Arpan R." last="Mehta">Arpan R. Mehta</name><name sortKey="Moore, James W" sort="Moore, James W" uniqKey="Moore J" first="James W." last="Moore">James W. Moore</name><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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